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【Anti-Aging】Fisetin

2024-07-18 17:23:34

Senolytics (senescent cell lysing agents) are a type of anti-aging drugs that can eliminate senescent cells. The more well-known ones include rapamycin, quercetin combined with dasatinib, etc.

An article in 1966 showed that fisetin was one of the flavonoids with the strongest antibacterial effect known at that time. It can effectively inhibit the growth of bacteria such as Staphylococcus aureus. In 2021, the University of Minnesota and the Mayo Clinic jointly released a study showing that senolytics significantly reduced the mortality rate of elderly mice infected with beta-coronavirus. This anti-aging drug is fisetin.

01 What is fisetin?

Fisetin, also known as fisetin, is a type of natural flavonoid compound extracted from plants such as Anacardiaceae. Fisetin is also found in fruits and vegetables and has antioxidant, anti-inflammatory and other pharmacological properties.

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02 What is the function of fisetin?

Fisetin is a bioflavonoid antioxidant that can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. It has the potential to cross the blood-brain barrier, which may help maintain neuronal function.

01.Fisetin can scavenge free radicals and enhance glutathione

Fisetin directly scavenges free radicals, enhances glutathione levels, and may help regulate the production of many proteins involved in protecting the body from oxidative stress and maintaining redox homeostasis. This is the mechanism by which glutathione achieves its antioxidant effects.

02.Fisetin also has anti-tumor effects.

Activity experiments have proven that it has anti-human lung cancer cells, anti-uterine cancer cells, anti-human skin cancer cells and anti-human colon cancer cells. Its main mechanism is to induce the organ differentiation of cancer cells into normal cells by transforming cancer cell genes.

03.Fisetin also has unique effects on brain health, cognition and memory.

Much of the research on this has been conducted at the renowned Salk Institute for Biological Studies in San Diego, focusing on its use as a "nootropic substance" and "neurotrophic factor." As mentioned before, it can cross the blood-brain barrier and then exert a "pruning" effect, clearing out senescent cells and allowing healthy cells to replace old, useless and possibly harmful cells. And, some people believe that its ability is due to quercetin. Twice as much as the prime.

03 Summarize

Fisetin is a natural compound extracted from plants that has many benefits and is a member of the senolytics group for its role in clearing senescent cells. There are many fisetin products on the market now. If you have anti-aging ideas, I believe fisetin is a good choice.

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