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Relationship between resveratrol and human health
2024-07-24 11:56:08
Resveratrol, a non-flavonoid polyphenol organic compound, is an antitoxin produced by many plants when stimulated, with the chemical formula C14H12O3. It can be synthesized in grape leaves and grape skins and is a bioactive ingredient in wine and grape juice. Resveratrol and its derivatives are mainly found in at least 72 species of plants in 31 genera and 21 families such as Vitis, Polygonum, peanut and veratrol, including common medicinal plants such as knotcane, cassia and mulberry, as well as crops such as grapes and peanuts. The main natural sources of resveratrol are knotweed and grapes. Resveratrol is easily absorbed by mouth and excreted in urine and stool after metabolism. In vitro and animal experiments have shown that resveratrol has antioxidant, anti-inflammatory, anticancer and cardiovascular protective effects. Exploring the relationship between resveratrol and human health is conducive to promoting the deep processing and utilization of resveratrol and improving human health.
CONCLUSION
Experiments have shown that pre-intervention with resveratrol can prevent iris-induced liver injury. At the same time, resveratrol was found to inhibit liver inflammation during HIRI by affecting neutrophils. The mechanism by which resveratrol regulates neutrophils is to inhibit neutrophils survival, cell cycle, migration chemotaxis, oxidative stress, cytokine secretion and endothelin-1 autocrine by inhibiting ERK signaling pathway. These data provide more evidence for the immunomodulatory effects of resveratrol and enrich our understanding of immune strategies to improve HIRI.
Reference:
WANG Y N, SUN X J, HAN X T, et al. Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114358. DOI:10.1016/j.biopha.2023.114358.
Based on comprehensive preclinical studies, resveratrol exerts chemoprotective and chemosensitizing effects through anti-plasticity, antioxidant, anti-inflammatory, and pro-apoptotic modes of action. In addition to its anticancer effects, resveratrol also acts as a moderator of chemotherapy-induced toxicity in normal cells/tissues. As an anti-tumor drug (targeting multiple mechanisms), drug combination improves its therapeutic effect through superposition and synergy, and reduces the effects of chemotherapy resistance.
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In summary, this article reviews the chemical sensitization effect of resveratrol on tumor cells to chemotherapy drugs from the perspective of cell plasticity, which is of great significance to the adaptability of cells to the TME during tumor cell transformation and metastasis. This also provides new impetus for further research on cancer epigenetics and resveratrol-mediated plasticity inhibition, strongly suggesting that resveratrol, as an active phytochemical, will play a role in the prevention and treatment of CRC in the future. important role.
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