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NMNH, kahi moʻolelo a me ka mana NAD precursor

ʻO ka hale mana ma lalo o ka honua anti-old - NMNH

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He ʻatikala e heluhelu ai i ka NMN-Mahele ʻElua

2024-08-19 13:54:49

Pehea e hoʻonui ai i ka ʻike NAD + i ke kino o ke kanaka?

Me ka hohonu o ka noiʻi, ua ʻike ʻia ka nicotinamide mononucleotide (NMN), ka precursor o NAD +, ʻo ia ka mea hoʻohui NAD + kūpono.

Ua ʻike nā hoʻokolohua ʻepekema ma hope o ka lawe ʻanaNMNma ka waha, e komo i ke koko i loko o 2-3 mau minuke, e hoʻonui i ka ʻike NMN i loko o ke kino i loko o 15 mau minuke, a hoʻonui i ka ʻike NAD + i loko o ke kino i loko o 30 mau minuke, a laila e loaʻa ai nā hopena like ʻole o ka lohi ʻana i ka ʻelemakule.

I ka makahiki 2013, ua hōʻoia nā hoʻokolohua ma ke Kulanui ʻo Harvard ʻo Paul Glenn Center on Aging e hiki i ka NMN ke hoʻonui i ke ola o nā mammals ma mua o 30%.

Ma 2016, he hui noiʻi i alakaʻi ʻia e Shinichiro Imai, he polopeka ma ke Kulanui o Wakinekona ma ʻAmelika Hui Pū ʻIa, hoʻopuka i kā lākou mau hopena noiʻi ma ka puke moʻolelo ʻepekema ʻAmelika Cell Metabolism: ua hōʻoia ʻia ka hopena anti-aging o NMN, a hoʻomaka lākou e hoʻāʻo. noi kanaka.

I ka makahiki 2018, ua paʻi ʻo ke kaukaʻi ʻo Harvard Medical School ʻo David Sinclair i nā hopena hoʻokolohua ma ka puke moʻolelo hoʻonaʻauao mana "Cell", kahi i hōʻoia hou i ka hana anti-aging o NMN.

Ua alakaʻi ʻia nā noiʻi ʻepekema kaulana e like me ke Kulanui ʻo Harvard ma ʻAmelika Hui Pū ʻIa, Ke Kulanui o Wakinekona, a me Ke Kulanui ʻo Keio ma Iapana i nā noiʻi he nui ma NMN, a ua paʻi ʻia nā hopena kūpono ma nā puke hoʻonaʻauao mana e like me Cell, Nature, and Science. Ua hui pū ʻo NASA i ka noiʻi ma NMN. Manaʻo lākou hiki iā NMN ke hoʻoponopono i ka pōʻino DNA a pale i nā astronauts mai nā kukuna cosmic.

No ke aha e koho aiNMN?

Nui nā NAD + precursors, no ke aha e koho ai iā NMN?

Mai ka hiʻohiʻona o ka hoʻohui ʻana i ka NAD +, nā precursors hiki ke hoʻohui i nā pōʻai metabolic ʻekolu o NAD +: niacin, tryptophan, nicotinamide, nicotinamide ribose (NR) a me NMN.

ʻO ka hoʻololi ʻana o tryptophan i NAD + pono i 8 mau ʻanuʻu;

ʻO ka hoʻololi ʻana o ka nicotinamide i NAD + e pono ai i nā ʻanuʻu 3;

ʻO ka hoʻololi ʻana o ka nicotinamide ribose (NR) i NAD + e koi i 2 mau ʻanuʻu;

Ka hoohuli ana oNMNi NAD + pono 1 wale nō kaʻina.

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No ka mea ʻaʻole paʻa ʻo NAD + i ke kaiapuni a loaʻa ke kaumaha molekala nui ʻaʻole hiki ke hoʻopili pololei ʻia, ʻaʻole hiki ke hoʻohui ʻia i waho.

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