Senolytics (senescent cell lysing agents) bụ ụdị ọgwụ mgbochi ịka nká nke nwere ike iwepụ mkpụrụ ndụ senescent. Ndị a maara nke ọma gụnyere rapamycin, quercetin jikọtara ya na dasatinib, wdg.
Otu isiokwu e mere na 1966 gosiri nke ahụ
fisetinbụ otu n'ime flavonoids nwere mmetụta nje nje kachasi ike mara n'oge ahụ. Ọ nwere ike igbochi uto nke nje bacteria dị ka Staphylococcus aureus nke ọma. Na 2021, Mahadum Minnesota na Mayo Clinic jikọrọ aka weputara ọmụmụ na-egosi na senolytics belatara ọnụ ọgụgụ ọnwụ nke ụmụ oke ndị agadi bu beta-coronavirus. Ọgwụ mgbochi ịka nká a bụ fisetin.
01 Gịnị bụ fisetin?
Fisetin, nke a makwaara dị ka
fisetin, bụ ụdị ngwakọta flavonoid eke ekepụtara na osisi dịka Anacardiaceae. A na-ahụkwa Fisetin na mkpụrụ osisi na akwụkwọ nri ma nwee antioxidant, mgbochi mkpali na ọgwụ ndị ọzọ.
02 Gịnị bụ ọrụ nke fisetin?
Fisetin bụ antioxidant bioflavonoid nke nwere ike inye aka ịnọgide na-enwe ọkwa glutathione na ọrụ mitochondrial na ọnụnọ nke nrụgide oxidative. O nwere ikike ịgafe ihe mgbochi ụbụrụ ọbara, nke nwere ike inye aka ịnọgide na-arụ ọrụ neuronal.
01.Fisetinnwere ike ịbọ ọbọ free radicals ma welie glutathione
Fisetin na-ekpochapụ radicals n'efu, na-eme ka ọkwa glutathione dịkwuo elu, ma nwee ike inye aka ịhazi mmepụta nke ọtụtụ protein ndị na-etinye aka n'ichebe ahụ site na nrụgide oxidative na ịnọgide na-enwe redox homeostasis. Nke a bụ usoro nke glutathione na-enweta mmetụta antioxidant ya.
02.Fisetin nwekwara mmetụta mgbochi tumor.
Nnwale ihe omume egosila na o nwere mkpụrụ ndụ kansa akpa ume mmadụ na-egbochi mmadụ, mkpụrụ ndụ kansa na-egbochi uterine, mkpụrụ ndụ kansa anụ ahụ na-egbochi mmadụ na mkpụrụ ndụ kansa eriri afọ mmadụ. Usoro ya bụ isi bụ ime ka akụkụ ahụ dị iche iche nke mkpụrụ ndụ kansa banye n'ime sel nkịtị site n'ịgbanwe mkpụrụ ndụ mkpụrụ ndụ kansa.
03.Fisetin nwekwara mmetụta pụrụ iche na ahụike ụbụrụ, ọgụgụ isi na ebe nchekwa.
Ọtụtụ n'ime nchọpụta a na-eme na nke a ma ama na Salk Institute for Biological Studies na San Diego, na-elekwasị anya na iji ya dị ka "ihe nootropic" na "ihe na-akpata neurotrophic." Dị ka e kwuru na mbụ, ọ nwere ike ịgafe ihe mgbochi ụbụrụ nke ọbara wee nwee mmetụta "ịkwachaa", na-ekpochapụ sel ndị na-eri anụ na ikwe ka sel ahụ dị mma dochie sel ochie, nke na-abaghị uru na nke nwere ike imerụ ahụ. Na, ụfọdụ ndị kwenyere na ikike ya bụ n'ihi quercetin. Ugboro abụọ ka nke mbụ.
03 Kọwaa
Fisetin bụ ihe sitere n'okike ewepụtara na osisi nwere ọtụtụ uru ma bụrụ onye otu senolytics maka ọrụ ya na ikpochapụ mkpụrụ ndụ senescent. Enwere ọtụtụ
fisetinngwaahịa na ahịa ugbu a. Ọ bụrụ na ị nwere echiche mgbochi ịka nká, ekwenyere m na fisetin bụ nhọrọ dị mma.
Maka ihe ndị ọzọozigbasara ngwaahịa na ọrụ anyị biko kpọtụrụ anyị.
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Irene@xahealthway.com
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