When it comes to berberine, many people will be unfamiliar with it. However, when it comes to the familiar saying "A dumb man eats Coptis chinensis - he can't tell the pain", everyone immediately understands it. The bitterness of coptis described in this sentence is due to the berberine contained in it, which is what we call berberine.
Berberine (BBR) is a naturally occurring plant-derived polyphenol that exists in a variety of plants/herbal medicines. It is the main active ingredient in Coptis chinensis and Phellodendron cypress. It has a long history of medicinal use at home and abroad and has antibacterial, It has pharmacological effects such as anti-inflammatory, anti-gastric ulcer and treatment of jaundice.
01 Antibacterial effect
Berberine has strong pharmacological effects against bacteria, fungi and viruses. It is mainly used clinically to treat gastroenteritis, bacillary dysentery, scabies, suppurative otitis media and conjunctivitis. As a broad-spectrum antibacterial drug, berberine can inhibit the attachment of Gram-positive bacteria and Gram-negative bacteria by reducing the number of pili on the bacterial surface.
02 Anti-inflammatory effect
The anti-inflammatory effect of berberine has been discovered for decades. In the early years, it was found that berberine can alleviate the inflammatory response caused by cholera toxin in rats; in addition, berberine can inhibit the inflammatory factors IL-1 and IL-6 and the secretion of TNF, showing strong anti-inflammatory effects on inflammation involving macrophages.
03 New uses for old medicines
Research has found that berberine hydrochloride and its derivatives have good performance in treating many aspects such as lowering blood sugar, lowering blood lipids, anti-atherosclerosis, mental illness, immune system diseases, Alzheimer's disease, tumors, etc. New pharmacological effects of berberine hydrochloride are gradually discovered, and the discovery of these new effects also provides new possibilities for the future clinical application of berberine hydrochloride.
03-A hypoglycemic effect
Reportedly useful in the treatment of type 2 diabetes. Berberine can reduce glucagon, improve insulin resistance, and promote pancreatic beta cell regeneration and functional recovery. The mechanism is: under glucose stimulation, berberine hydrochloride can increase insulin secretion and cell proliferation in pancreatic islet cells, acting as an insulin secretagogue.
03-B hypolipidemic effect
It can lower blood lipids and reduce the occurrence of atherosclerosis. The mechanism is: berberine activates the AMP-dependent protein kinase (AMPK) pathway to upregulate lipolysis-related genes, inhibit the expression of fat synthesis genes, reduce triglyceride levels, and achieve the effect of regulating blood lipids.
03-C Anti-atherosclerotic effect
The effects of berberine in inhibiting atherosclerosis include improving endothelial dysfunction; inhibiting smooth muscle cell proliferation and migration; reducing monocyte adhesion, macrophage inflammation, and cholesterol aggregation, foam cell formation, and platelet aggregation.Future prospects
Some time ago, the FDA approved the marketing of Resmetirom for the treatment of patients with stage F2-F3 NASH (non-alcoholic steatohepatitis). Berberine has significant therapeutic effects on NASH by regulating lipid metabolism and insulin resistance. Berberine exerts its autophagy-enhancing effect through liver SIRT1, thereby downregulating the level of lipid deposition in hepatocytes and improving fatty liver. Activation of the berberine-SIRT1-FGF21 axis may become a new way to treat obesity by promoting browning of adipose tissue and enhancing energy consumption. This study found through animal experiments that berberine can reduce the fat content in the liver, improve insulin resistance, and reduce inflammatory responses, thereby alleviating the pathological manifestations of NASH. As the first new NASH drug, Rezdiffra, we stay tuned to see if berberine may have a new breakthrough in the treatment of non-alcoholic steatohepatitis in the future.
The above scope of use has not been approved in our country, so you must strictly follow the doctor's advice.
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Post time: May-10-2024
