Senolytics (senescent cell lysing agents) ndi mtundu wa mankhwala oletsa kukalamba omwe amatha kuthetsa ma cell a senescent. Odziwika kwambiri ndi rapamycin, quercetin ophatikizidwa ndi dasatinib, etc.
Nkhani ina mu 1966 inasonyeza zimenezo
fisetininali imodzi mwa flavonoids yokhala ndi antibacterial yamphamvu kwambiri yomwe imadziwika panthawiyo. Ikhoza kulepheretsa kukula kwa mabakiteriya monga Staphylococcus aureus. Mu 2021, University of Minnesota ndi Mayo Clinic pamodzi adatulutsa kafukufuku wosonyeza kuti senolytics amachepetsa kwambiri kufa kwa mbewa okalamba omwe ali ndi beta-coronavirus. Mankhwala oletsa kukalamba awa ndi fisetin.
01 Kodi fisetin ndi chiyani?
Fisetin, yemwe amadziwikanso kuti
fisetin, ndi mtundu wa flavonoid wachilengedwe wotengedwa ku zomera monga Anacardiaceae. Fisetin imapezekanso mu zipatso ndi ndiwo zamasamba ndipo imakhala ndi antioxidant, anti-inflammatory and other pharmacological properties.
02 Kodi fisetin imagwira ntchito bwanji?
Fisetin ndi bioflavonoid antioxidant yomwe ingathandize kusunga milingo ya glutathione ndi ntchito ya mitochondrial pamaso pa kupsinjika kwa okosijeni. Imakhala ndi mwayi wodutsa chotchinga chamagazi-muubongo, chomwe chingathandize kusunga ntchito ya neuronal.
01 .Fisetinimatha kuwononga ma free radicals ndikuwonjezera glutathione
Fisetin imatulutsa mwachindunji ma radicals aulere, imakulitsa milingo ya glutathione, ndipo imatha kuthandizira kupanga mapuloteni ambiri omwe amakhudzidwa ndi kuteteza thupi ku kupsinjika kwa okosijeni ndikusunga redox homeostasis. Iyi ndi njira yomwe glutathione imakwaniritsa zotsatira zake za antioxidant.
02.Fisetin imakhalanso ndi zotsatira zotsutsana ndi zotupa.
Zoyeserera zantchito zatsimikizira kuti ili ndi maselo odana ndi khansa ya m'mapapo, ma cell odana ndi chiberekero, ma cell a khansa yapakhungu yamunthu komanso ma cell a khansa ya m'matumbo amunthu. Njira yake yayikulu ndikupangitsa kuti ma cell a khansa asiyanitse kukhala ma cell abwinobwino posintha ma cell a khansa.
03.Fisetin imakhalanso ndi zotsatira zapadera pa thanzi laubongo, kuzindikira ndi kukumbukira.
Kafukufuku wambiri pa izi wachitika ku Salk Institute for Biological Studies ku San Diego, poyang'ana ntchito yake monga "nootropic substance" ndi "neurotrophic factor." Monga tanena kale, imatha kuwoloka chotchinga chamagazi-muubongo ndikuchita "kudulira", kuchotsa ma cell a senescent ndikulola maselo athanzi kuti alowe m'malo akale, opanda pake komanso owopsa. Ndipo, anthu ena amakhulupirira kuti kuthekera kwake ndi chifukwa cha quercetin. Kawiri kuposa choyambirira.
03 Fotokozerani mwachidule
Fisetin ndi chilengedwe chochokera ku zomera zomwe zimakhala ndi ubwino wambiri ndipo ndi membala wa gulu la senolytics chifukwa cha ntchito yake yoyeretsa maselo a senescent. Pali zambiri
fisetinkatundu pa msika tsopano. Ngati muli ndi malingaliro oletsa kukalamba, ndikukhulupirira kuti fisetin ndi chisankho chabwino.
Kuti mudziwe zambirizambiriza malonda ndi ntchito zathu chonde titumizireni.
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