Ukuze uqhathanise imiphumo ye-NMNH kunye ne-NMN, abaphandi bafaka i-PBS kunye ne-250 mg / kg ye-NMN kunyeNMNHkwiimpuku ze-C57BL/6N, ngokulandelelanayo, emva koko zenze iisampulu zegazi ezilandelelanayo. Iziphumo zibonise ukuba i-NMNH yandisa kakhulu amanqanaba e-NAD egazini, ukuya kumlinganiselo omkhulu kune-NMN. I-NAD yalinganiswa kwizicubu eziqokelelweyo ngokusebenzisa indlela yomjikelezo we-enzyme. Iziphumo zibonise ukuba i-NMNH yandise amanqanaba e-NAD kwii-tissue ezahlukeneyo, kwaye umphumo wawuphezulu kune-NMN. Yayinempembelelo ecacileyo kwisibindi kunye nezintso, kunye nesibindi sanda ngamaxesha angaphezu kwama-5 kunye nezintso zanda ngamaxesha angaphezu kwama-5. 2 amaxesha.
I-NMNH yongezwa ngexesha lesigaba se-reoxygenation, kwaye ukubonakaliswa kwe-renal tubular marker yokulimala kwe-KIM-1 kwafunyanwa. I-Reoxygenation kwi-TEC ibangele ukunyuka okubukhali kwi-KIM-1 intetho, eyehla ngokukhawuleza emva konyango lwe-NMNH, ebonisa ukuba ulawuloNMNHinokunciphisa ngokufanelekileyo kunye nokunciphisa umonakalo kwiiseli ze-renal tubular epithelial ngexesha le-hypoxia kunye ne-reoxygenation.
Indlela yempiloNMNHudubulo lokwenyani
Kugxilwe kwishishini lotyalo-gazi iminyaka emininzi
Lawula ngokungqongqo ukukhethwa kwezinto ezikrwada kunye nokuseka isiseko sokutyala
Uvavanyo oluqhelekileyo lovavanyo, ukuveliswa komgangatho ophezulu
Isicatshulwa se-Epimedium, sinobuchwephesha
Ubonelelo olukumgangatho ophezulu, wamkelekile ukwenza iodolo!!
